| Pair Name | Gossypol, Fluorouracil | ||
| Phytochemical Name | Gossypol (PubChem CID: 3503 ) | ||
| Anticancer drug Name | Fluorouracil (PubChem CID: 3385 ) | ||
| Structure of Phytochemical |
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2D
MOL
3D
MOL
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| Structure of Anticancer Drug |
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MOL
3D
MOL
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| Pair Name | Gossypol, Fluorouracil | |||
| Disease Info | [ICD-11: 2B90] | Colon cancer | Investigative | |
| Gene Regulation | Up-regulation | Cleavage | CASP3 | hsa836 |
| Down-regulation | Expression | CCND1 | hsa595 | |
| Down-regulation | Phosphorylation | MTOR | hsa2475 | |
| Up-regulation | Cleavage | PARP1 | hsa142 | |
| Down-regulation | Phosphorylation | RPS6KB1 | hsa6198 | |
| Down-regulation | Expression | TYMS | hsa7298 | |
| In Vitro Model | HT-29 | Colon adenocarcinoma | Homo sapiens (Human) | CVCL_0320 |
| HCT 116 | Colon carcinoma | Homo sapiens (Human) | CVCL_0291 | |
| RKO | Colon carcinoma | Homo sapiens (Human) | CVCL_0504 | |
| Result | These findings suggest that gossypol-mediated down-regulation of TS, cyclin D1, and the mTOR/p70S6K1 signaling pathways enhances the anti-tumor effect of 5-FU. Ultimately, our data exposed a new action for gossypol as an enhancer of 5-FU-induced cell growth suppression. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Gossypol sensitizes the antitumor activity of 5-FU through down-regulation of thymidylate synthase in human colon carcinoma cells. Cancer Chemother Pharmacol. 2015 Sep;76(3):575-86. doi: 10.1007/s00280-015-2749-0. | Click |
